Other bricks for the correct construction of the mitochondrial permeability transition pore complex

In recent years, the concept of the mitochondrial permeability transition pore (mPTP) has attracted considerable attention from researchers in the field of pathophysiology, focusing on mitochondrial function as a potential therapeutic target. Indeed, given that the mPTP is considered to be the main and final effector of cell death in various disorders, numerous and progressive efforts have been undertaken using this novel molecular target, both in clinical trials and especially in basic research. Although the exact structure of this supramolecular entity is largely unknown, studies beginning in 2013 have begun to elucidate the structure of the pore-forming component – the C subunit of the F1/FO ATP synthase. 5–8